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The third pandemic, stretching 1852–1860, was the deadliest. It devastated Asia, Europe, North America and Africa, killing 23,000 people in Great Britain alone in 1854, the worst single year of cholera. Cholera, and then show that the presence of the bacterium in intestines causes cholera.
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The third cholera pandemic (1846–60) was the third major outbreak of cholera originating in ... In 1852, cholera spread east to Indonesia, and later was carried to China and Japan in 1854. The Philippines were infected in 1858
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The virus also killed people directly by causing massive hemorrhages and edema in the lungs. Modern analysis has shown the virus to be particularly deadly because it triggers a cytokine storm (overreaction of the body's immune system).
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The 1889–1890 flu pandemic, also known as the "Asiatic flu" or "Russian flu", was a pandemic that killed about 1 million people worldwide, out of a population of about 1.5 billion. It was the last great pandemic of the 19th century.
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The sixth pandemic killed more than 800,000 in India. The last outbreak in the United States was in 1910–1911, when the steamship Moltke brought infected people from Naples to New York City. Vigilant health authorities isolated the infected in quarantine on Swinburne Island.
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The 1918 influenza pandemic was the most severe pandemic in recent history. It was caused by an H1N1 virus with genes of avian origin. Although there is not universal consensus regarding where the virus originated, it spread worldwide during 1918-1919.
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Ebola has killed 15,258 people and caused 29 epidemics since it was first detected in 1976.
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SARS killed 813 people in what health experts call a "near-pandemic" in 2002.
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AIDS-related deaths have fallen by 30% since the peak in 2005. In 2012, 1.6 million [1.4 million–1.9 million] people died from AIDS-related causes worldwide compared to 2.3 million [2.1 million–2.6 million] in 2005.
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H1N1 "swine flu" killed 284,000 people in what was the century's fifth flu pandemic.
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Chikungunya is a mosquito-borne virus that was first identified in 1952 and became pandemic in 2014. Deaths from this virus are uncommon.
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Zika is a type of flavivirus that has existed for decades. It wasn't until 2015 that the mosquito-borne virus spread pandemically, likely due to a virus mutation.
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In 2019, a new coronavirus was identified as the cause of a disease outbreak that originated in China. The virus is now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease it causes is called coronavirus disease 2019 (COVID-19).