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Griffith
Injected mice with heat-killed, disease-causing bacteria that “transformed” harmless bacteria into ones that can cause disease.“transforming factor” lead to question that maybe DNA carried the genetic information. -
Chargaff
Taking samples of DNA from various organisms and measuring the percentages of nucleotides present. Chargaff’s Rule; base pairing: adenine pairs with thymine and guanine pairs with cytosine-though he did not know why! -
Avery
Followed/repeated Griffith’s experiment. Yes, DNA stores and transmits genetic information from generation to the next. -
Linus Pauling and Robert Corey
Taking samples of proteins from various organisms. The structure of a class of proteins is a helix. -
Hershey-Chase
Used different radioactive markers to label the DNA and proteins of bacteriophages. Genetic material was DNA, not protein. -
Franklin
Using X-ray technique to take pictures of DNA. Developed the technique called X-ray diffraction, which lead to the discovery of the double helix shape of DNA. -
Watson and Crick
Be researching others work and manipulating models. DNAs structure is a double helix. -
Brenner
Measurements, observations, and repeating of others discoveries. Showed the existence of messenger RNA (mRNA). -
Gilbert
Measurements, observations, and repeating of others discoveries. Developed methods to read the DNA sequence.
