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Under the leadership of George Gey (the head of tissue culture research at Johns Hopkins), Lawrence Wharton sampled both malignant and healthy cervical cells to be subsequently grown in culture.
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In the year prior, a Polio epidemic became a public health crisis. James Salk of the University of Pittsburgh stated he had developed a vaccine for the virus. HeLa cells, which could incessantly grow in moving culture medium, were the perfect alternative to the comparatively costly cells of monkeys. Because HeLa cells were particularly susceptible to poliovirus, scientists at Johns Hopkins and Tuskegee were able to test the effectiveness of Salk’s vaccine.
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Since HeLa cells were a sample from a plethora of Lacks’s cervical cells, scientists cloned HeLa cells to isolate traits in individual cells. This was done by a group of Colorado scientists, and their breakthroughs subsequently assisted in stem cell isolation, IVF, and animal cloning.
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A Texas scientist made chromosomes in HeLa cells expand and separate by mixing the cells with the incorrect liquid. 46 chromosomes were determined to be the correct quantity, leading to the discoveries of genetic disorders due to an incorrect number of chromosomes (E.g. Down syndrome with an extra 21st chromosome, and Turner syndrome with a missing/partially missing sex chromosome).
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Southam non-consensually injected HeLa cells into both cancer patients and healthy Ohio prisoners. HeLa cells metastasized in current cancer patients, whilst being deterred by the immune systems of healthy individuals. Because of his research, some hoped that humans could inoculate individuals against cancer.
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It was discovered cells could fuse together when clumped in culture, via a process known as somatic cell fusion (AKA “cell sex”). Subsequently, Henry Harris and John Watkins fused human and mouse cells, eventually leading to the mapping of traits for particular genes.
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Geneticist Stanley Gartler’s study noted that HeLa cells may have contaminated innumerable cell cultures (describing his discovery as a “technical problem”), thus nullifying (or at least bringing into question), years of prior research.
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HeLa cells infected with virus to research how it attacks human cells.
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The German virologist Harald zur Hausen discovered that HeLa cells were infected with multiple strains of HPV-18, which he suspected led to cervical cancer. Eventually, it would be discovered that the virus inserted its DNA into Lacks’s cells, causing the p53 gene (which prevents tumors) to stop working. Eventually led to the development of an HPV vaccine.
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Richard Axel and others inserted DNA from blood cells into HeLa cells, making HeLa susceptible to HIV. This assisted in scientists better understanding the genetic conditions in which one can be infected by the virus.
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Telomerase, a substance found in cancer cells, regenerates telomeres at the ends of chromosomes (which normally unravel with age, leading to cell death). Due to this substance, cancer could grow and reproduce incessantly. Through this discovery, researchers could better understand cancer itself, as well as what held the onus for HeLa immortality.
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Researchers inserted the TB virus into HeLa cells in order to examine the manners in which the illness impacts human cells.
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HeLa cells were injected with nanoparticles by researchers, ones which could allocate necessary substances in order to less invasive in true procedures.