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The first permanent settlement in the U.S.
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The smallpox epidemic wipes out 90% of the Native Americans in the Massachusetts Bay area.
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The first representative assembly in America.
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The Puritans begin to establish a settlement in Plymouth. They also form the Mayflower Compact.
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York, Maine of the Massachusetts Colony become the first incorporated city in the American colonies.
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In the last Indian rebellion in the region, two tribes of Indians attack the English at Jamestown, but their effort is unsuccessful.
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Bacon's Rebellion causes the destruction of Jamestown. Nathanial Bacon leads the rebellion.
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First paper money issued in North America by the Massachusetts Bay Colony.