Major Biotech Innovations By jadencanales Feb 7, 1600 Robert Hooke coined 'cells' , Leeuwenhoek observed first microorganisms Period: Feb 7, 1600 to Feb 7, 1869 Before DNA Feb 7, 1850 Gregor mendel discovers simple inheritance laws predicting trait outcomes Apr 10, 1857 Lois Pasteur discovers fermentation and Germ theory Feb 7, 1869 Johann Mieshcer discovered DNA is inheritable Feb 7, 1910 Thomas Hunt Morgan discovered genes were on chromosomes Period: Feb 7, 1910 to Feb 7, 1967 DNA science Feb 7, 1928 Fred Griffith proved that genetic material can move from one bacteria to another Feb 7, 1928 Alexander Fleming isolated penicillin from fungus Feb 7, 1935 Chargaff showed that adenine pairs with thymine and cytosine pairs with guanine Feb 7, 1941 Beadle and Tatum "one gene, one enzyme" Feb 7, 1944 Avery, McCarty, and McLeod DNA is hereditary Feb 7, 1953 Hershey and Chase proved viruses replicated as DNA Feb 7, 1953 Rosalind Franklin established DNA is double helix Feb 7, 1953 Watson and Crick discovered DNA structure Feb 7, 1953 Hayes discovered plasmid DNA Feb 8, 1961 Walter GIlbert discovered gene expression through RNA Feb 8, 1962 Arber, Nathans, and Smith discovered enzymes that cut DNA Feb 8, 1966 Khorana, and Nirenberg discovered 64 codons(3 bases of DNA) Feb 8, 1967 DNA plasmids were isolated and purified by Vinograd Feb 8, 1970 Madel and Higa first transformation of bacterium Escherichia coli. Period: Feb 8, 1970 to Feb 8, 2003 Rcombinant DNA Tech Feb 14, 1972 cloning experiments conducted by boyer and cohen Feb 14, 1973 genetech was founded Feb 14, 1976 scientsts met to draw up guidelines for work with recombinant dna Feb 14, 1977 Sanger and Gilbert found a way to sequence DNA Period: Feb 14, 1977 to Feb 14, 1999 New tools Feb 14, 1978 boyer inserted a synthetic insulin gene into e.coli Feb 14, 1978 Botstein found that you can be identified by DNA Feb 14, 1978 Louise Joy Brown was born who was made in a petri dish Feb 14, 1980 Ohio University scientists made trasgenic animals Feb 14, 1980 The u.s supreme court ruled that genetically altered life forms can be patented Feb 14, 1982 Eli Lilly Company placed insulin gene in bacteria Feb 14, 1983 Schell, Chilton , Van Mantagu transformed plants Feb 14, 1983 Kary Mullins invented PCR to amplify DNA Feb 14, 1985 Jeffries apllied RFLP in DNA profiling Feb 14, 1985 An automated fluorescence sequencer was invented Feb 14, 1985 Fenes were moved into an organism through gene gun Feb 14, 1994 NIH revised safety guidelines Feb 14, 1996 Andrew Fire and Craig Mello discovered silencing of genes Feb 14, 1997 Kohler, Milstein, and Jerne used mab technology Feb 14, 1997 Maynard Olson Invented expression vectors for proteins Feb 14, 1997 Ian Wilmut cloned Dolly the sheep Feb 14, 1997 Ability to look at genes on slide was developed Feb 14, 1999 Dabiri and Garner made faster DNA sequencer Feb 14, 2002 Ron Breaker coined term riboswitch for mRNA Feb 14, 2003 Completion of Human Genome Project