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Nicolaus Copernicus published a book just before he died that presented his theory about the solar system. He said that the Earth couldn't be known to be the center of the universe because it was possible that the Sun was. He learned this by observing Mars and Saturn throughout the year, especially around the equinoxes.
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Tycho Brahe wrote De Nova Stella in 1573 which explained that the births of stars and supernova where not phenomena that happened within our atmosphere. He stated that these occurences were outside of our atmosphere and past the moon.
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In 1609, Kepler published his first two laws of planetary motion. Ten years later, in 1619, he published his third law. He explained how the planets moved around the sun and other facts that played important roles in the Scientific Revolution.
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Galileo discovered three moons orbiting Jupiter which proved that not everything orbited the Earth. This discovery meant that the Earth was not necessarily the center of the universe.
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William Harvey was a doctor in England who explained how the the circulatory system in humans and animals. He stated that the heart pumps blood throughout the veins and to all parts of the body with each beat.
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Boyle is most famous for Boyle's Law. This law states that when either the pressure or volume of a gas is increases by a certain number, the other decreases by the inverse of that number. This was an important discovery in chemistry and played a big role in science.
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Isaac Newton is most famous for his three universal laws of planetary motion published in his Principia. These explained how and why objects move the way they do and how gravity influences them.