Top 10 worst diseases in the world By syedmuhammadomer 165 Antonine Plague(165-180) 541 Plague of Justinian (541-542) 1346 The Black death(1346-1353) 1545 Cocliztli (1545-1548) and (1576-1578) 1852 The Third Cholera Pandemic (1852-1860) 1855 The Third Plague Pandemic(1855-1959) 1891 HIV/AIDS (1891-Present) 1918 The World War 1 Typhus Epidemic (1918-1922) 1918 1918 Flu Pandemic(1918-1920) 1956 Asian Flu Pandemic of 1957 (1956-1958)