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Hideyoshi was aghast by the massive slavery conducted on his people and blamed the Portuguese and Jesuits and banned Christianity. He wrote the letter to demand the purchase of Japanese slaves to stop, and for all Japanese slaves to be returned.
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This marks the beginning of the Edo Period. Tokugawa led Japan to its first golden age, trade with Europeans countries, population increasing, infrastructure established, education becoming wide spread, economic growth, and much more.
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England closed its Japanese base at Hirado Island without notifying Japan, effectively ending any contact since soon after Japan closes its borders.
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After Hideyoshi's Korean invasions depleted Ming Dynasty's resources, the Qing Dynasty began.
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Philip Franz von Siebold was stationed to Japan from Netherlands. He established the medical school Narutaki Juku which allowed Japanese scientists to learn western medicine.
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In 1854, Commodore Perry tries to force Japan open its borders, ending two and a half centuries of isolation.
