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Born
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Discovered a new species of bacteria: Salmonella enterica, formerly called Salmonella choleraesuis
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Along Daniel E. Salmon started working on the Texas fever, presented the first proof that killed bacteria could be used to induce active immunity in experimental animals.
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Started experimenting with cows and ticks, and described little bodies in the erythrocytes of infected cattle.
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He recognized the little bodies as protozoa, which he eventually named Piroplasma bigeminum (now called Babesia bigemina).
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The experiment with cows demonstrated that the infection could pass in ticks from adults to nymphs, a new and extraordinary phenomenon of parasitism.
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Reported that blackhead, an economically devastating enterohepatitis of turkeys, was caused by a protozoan called Amoeba meleagridis (now Histomonas meleagridis).
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Resolved the puzzle of transmission by discovering that embryonated eggs of the intestinal roundworm Heterakis papillosa (now Heterakis gallinae) could transmit the amoebas.
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He was one of the first to demonstrate the production of immunity by killed cultures of disease organisms and to show that a mixture of diphtheria toxin and antitoxin confers immunity.
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Joined the Rockefeller Institute for Medical Research as director of the Department of Animal Pathology, in Princeton, New Jersey.
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Established the criteria to distinguish between types of tubercle bacilli that affect humans and bovines. Smith took the position that the bovine organism could infect humans but was not the usual source of human infection.
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He retired
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Dies