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In about 1595, Zacharias Janssen invented the mircoscope.
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Robert Hooke, looked at a silver cork through a microscope lens and noticed some "pores" or "cells" in it.
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Anton van Leeuwenhoek built a simple microscope with only one lens to examine blood, yeast, insects and many other tiny objects.
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Technical innovations improved microscopes, leading to microscopy becoming popular among scientists.
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Joseph Jackson Lister reduces spherical aberration or the "chromatic effect" by showing that several weak lenses used together at certain distances gave good magnification without blurring the image.
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Ernst Abbe, then research director of the Zeiss Optical Works, wrote a mathematical formula called the "Abbe Sine Condition".
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Richard Zsigmondy developed the ultramicroscope that could study objects below the wavelength of light.
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Frits Zernike invented the phase-contrast microscope that allowed for the study of colorless and transparent biological materials.
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Gerd Binnig and Heinrich Rohrer invented the scanning tunneling microscope that gives three-dimensional images of objects down to the atomic level.