- 
  
  Alexander Cartwright introduces the first rules of baseball that were adopted by many.
- 
  
  Amherst College and Williams College played the first intercollegiate baseball game ever, which Amherst College won.
- 
  
  The beginning of the Major League is born.
- 
  
  The Major League introduced athe American League in addition to the National League as a rival.
- 
  
  The Boston Americans win the very first World Series ever to be played.
- 
  
  Comisky Park in Chicago, IL hosts the first ever baseball All Star game.
- 
  
  The first Hall of Fame class in Cooperstown, NY was Ty Cobb, Walter Johnson, Christy Mathewson, Babe Ruth, and Honus Wagner.
- 
  
  The first pick of the draft goes in order from the team with the worst record to the best.
- 
  
  College baseball allows the use of metal composite bats in addition to the traditional wooden bats.
- 
  
  Ron Blomberg of the New York Yankees becomes the first designated hitter ever in Major League history when the Boston Red Sox faced off against the New York Yankees.
- 
  
  Instant replay was used for the first time in the history of baseball to review the original call of an umpire.
