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A big plague started developing Asia around the 1300's because of the bad hygiene.
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The plague was spread to Europe mainly because the trading, some animals that lived among the humans, such as birds, rats or fleas that transmitted within the cloth, pillows, blankets etc.
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When the plague started invading Europe people didn't know how to face the sickness so people were sent to quarantines, but this strategy didn't obtain good results.
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The plague continued growing and killing thousands of people including kings, peasants, lords among others.
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The Black Plague finished with 1/3 of Europe population (25 million people) and the hierarchy was erased from Europe with a surplus of food and an industrial crisis.
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Plague disappeared from the world with the last case in Moscow and no other reports of the sickness' symptoms and years after the plague threatened to appear again but it only remained in a warning.