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It's started in 1346 is an infectious disease caused by Yersinia pestis, a zoonotic bacterium that is usually found in small mammals and the fleas that parasitize them. -
The plague might have reduced the world population from c. 475 million to 350–375 million in the 14th century
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The pandemic was reportedly first introduced to Europe during the siege of the Genoese trading port of Kaffa in Crimea by the Golden Horde army of Jani Beg in 1347.
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The 1347 pandemic plague was not referred to specifically as "black" in the time of occurrence in any European language, though the expression "black death" had occasionally been applied to fatal disease beforehand.
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It is the most fatal pandemic recorded in human history, causing the deaths of 75–200 million people