Spain in the 15th and 16th centuries By adrian.gaertner Oct 19, 1469 Marriage Catholics Monarchs Jan 2, 1492 Conquest of Granada Mar 31, 1492 Expulsion of the jews Oct 12, 1492 Discovery of America Nov 26, 1504 Death of Isabel I of Castilla Jul 25, 1512 Conquest of Navarra Mar 14, 1516 Beginning of Carlos I's reing Jan 15, 1556 Beginning of Felipe II's reing Feb 13, 1561 Capital city in Madrid Oct 7, 1571 Battle of Lepanto 1578 Conquest of Portugal