SID Disease Mechanisms: Autoimmune Blistering Diseases

  • Careful Description of Pemphigus Vulgaris

    Careful Description of Pemphigus Vulgaris
    McBride may have described the first cases of pemphigus vulgaris ever documented.
  • Pemphigus Foliaceus Described

    Cazenave is credited with identifying the subtype in 1844
  • Clinical Distinction of Dermatitis herpetiformis

    Duhring publishes his findings in JAMA in August 1884
  • Increased PV in Jewish Population

    JJ Eller and LH Kect publish findings for 77 cases in Arch Derm in 1941.
  • Discovery of Acantholysis

    In 1943, A. Civatte discovered the loss of cell-cell adhesion (acantholysis) in pemphigus and differentiated this histology from the subepidermal blisters of what was likely bullous pemphigoid and/or dermatitis herpetiformis.
  • Bullous Pemphigoid Defined as Distinct Disease

    W. Lever clearly defines bullous pemphigoid as a disease disctinct from pemphigus, and also from dermatitis herpetiformis as defined by Duhring in 1884.
  • Skin Antibodies Detected in PV via IF Staining

    Skin Antibodies Detected in PV via IF Staining
    E. H. Buetner and R. E. Jordan demonstrate the existence of skin antibodies in sera of pemphigus vulgaris patients using indirect immunoflourescent staining. *Image courtesy of Dermatopathology Lab, Stanford University
  • Mouse H2 linked to Viral Leukemogenesis

    Lilly et al publish evidence of the genetic basis of susceptibility to viral leukaemogenesis.
  • IgA Associated with Dermatitis Herpetiformis

    Cormane publishes findings ,"Immunoflourescent studies of the skin in lupus erythematosus and other diseases".
  • Increased HLA-B8 and W15 in lupus

    RH Cormane publishes findings, "Immunofluorescent studies of the skin in lupus erythematosus and other diseases"
  • Linear IGA disease

    Linear IGA disease
    Chorzelski et al find linear IgA at the basement membrane zone in some patients who now are felt to have linear IgA disease, which can mimic dermatitis herpetiformis. Publish in May 1971 JID.
    Image Courtesy JID Milestones
  • Link between HLA-B8 and DH

    S. I. Katz et al find a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy. Published in JCI Nov 1972.
  • Increased HLA-13 in Pemphigus Vulgaris

    Katz et al find increased levels of HLA-13 in patients with Pemphigus Vulgaris
  • DH improves with gluten-free diet

    Fry et al publish findings that indicate reduction of skin lesions in dermatitis herpetiformis after gluten withdrawal. Lancet August 11, 1973.
  • Increased Frequency of HL-A10 in PV Among Jewish Patients

    Krain et al discover increased frequency of HL-A10 in pemphigus vulgaris in nonrelated Jewish patients. December issue Archives of Dermatology.
  • Autoantibodies Cause Pemphigus Blister

    Schiltz and Michel find that autoantibodies actually cause the blister of pemphigus-shown in human skin organ culture. Published in April 1976 JID.
  • IgG, Complement and Inflammatory Cells Needed for Blister Formation

    Gammon et al find that in vitro models indicated that not only IgG but complement and inflammatory cells were necessary for blister formation in pemphigoid. October 1980 JID.
  • Bullous Pemphigoid Antigens Identified and Cloned

    Stanley et al, Labib et al and Diaz et al publish evidence (1981, 1986, and 1990 respectively) of two different bullous pemphigoid antigens BP230, BP180 in hemidesmosome.
  • Passive Transfer of Pemphigus to Newborn Mice

    Anhalt and Diaz discover Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. May 20, 1982 NEJM.
  • EBA Can Mimic Multiple Features of BP

    Gammon et al find that that a BP-like clinical presentation occurs in as many as 50% of EBA patients, and suggest that 10% of patients referred to medical centers and diagnosed as BP have EBA. November 1984 JAAD.
  • Type VII Collagen is Antigen in Acquired EB

    Woodlet et al find that Epidermolysis bullosa acquisita antigen is a glycoprotein with collagenous domains, and a new major component of the basement memberane. June 1986 JID.
  • HLA DQbeta Allele Associated with Pemphigus Vulgaris

    Sinha et al find nucleotide sequence of a class II variant found almost exclusively in patients with the autoimmune skin disease pemphigus vulgaris. Science 1988.
  • Fogo Selvagem Studies

    Variety of studies published throughout the 1990's on Fogo Selvagem, Portuguese for 'wild fire'.
  • Pemphigus Foliaceus Antigen is a Glycoprotein

    Koulu et al
  • PV Antigen Desmoglein 34

    Amagai et al find that a novel epithelial cadherin is the target of autoantibodies in PV. Cell Nov 1991.
  • PB180 is Antigien in Bullous Pemphigoid

    Lui et al publish findings that autoantibodies that recognize the human BP180 ectodomain are therefore likely to play an initiatory role in the pathogenesis of bullous pemphigoid and herpes gestationis. Nov 1993 JCI.
  • ELISA Developed to Detect anti-BP180 Autoantibodies

    Guidice et al developed ELISA system to detect antibody reactivity against the MCW-1 epitope with the use of a bacterial fusion protein containing the BP180 autoantibody-reactive site.
    June 1994 JID.