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McBride may have described the first cases of pemphigus vulgaris ever documented.
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Cazenave is credited with identifying the subtype in 1844
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Duhring publishes his findings in JAMA in August 1884
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JJ Eller and LH Kect publish findings for 77 cases in Arch Derm in 1941.
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In 1943, A. Civatte discovered the loss of cell-cell adhesion (acantholysis) in pemphigus and differentiated this histology from the subepidermal blisters of what was likely bullous pemphigoid and/or dermatitis herpetiformis.
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W. Lever clearly defines bullous pemphigoid as a disease disctinct from pemphigus, and also from dermatitis herpetiformis as defined by Duhring in 1884.
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E. H. Buetner and R. E. Jordan demonstrate the existence of skin antibodies in sera of pemphigus vulgaris patients using indirect immunoflourescent staining. *Image courtesy of Dermatopathology Lab, Stanford University
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Lilly et al publish evidence of the genetic basis of susceptibility to viral leukaemogenesis.
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Cormane publishes findings ,"Immunoflourescent studies of the skin in lupus erythematosus and other diseases".
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RH Cormane publishes findings, "Immunofluorescent studies of the skin in lupus erythematosus and other diseases"
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Chorzelski et al find linear IgA at the basement membrane zone in some patients who now are felt to have linear IgA disease, which can mimic dermatitis herpetiformis. Publish in May 1971 JID.
Image Courtesy JID Milestones
http://www.nature.com/milestones/skinbio3/full/skinbio20081a.html -
S. I. Katz et al find a genetic link between dermatitis herpetiformis and gluten-sensitive enteropathy. Published in JCI Nov 1972.
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Katz et al find increased levels of HLA-13 in patients with Pemphigus Vulgaris
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Fry et al publish findings that indicate reduction of skin lesions in dermatitis herpetiformis after gluten withdrawal. Lancet August 11, 1973.
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Krain et al discover increased frequency of HL-A10 in pemphigus vulgaris in nonrelated Jewish patients. December issue Archives of Dermatology.
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Schiltz and Michel find that autoantibodies actually cause the blister of pemphigus-shown in human skin organ culture. Published in April 1976 JID.
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Gammon et al find that in vitro models indicated that not only IgG but complement and inflammatory cells were necessary for blister formation in pemphigoid. October 1980 JID.
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Stanley et al, Labib et al and Diaz et al publish evidence (1981, 1986, and 1990 respectively) of two different bullous pemphigoid antigens BP230, BP180 in hemidesmosome.
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Anhalt and Diaz discover Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. May 20, 1982 NEJM.
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Gammon et al find that that a BP-like clinical presentation occurs in as many as 50% of EBA patients, and suggest that 10% of patients referred to medical centers and diagnosed as BP have EBA. November 1984 JAAD.
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Woodlet et al find that Epidermolysis bullosa acquisita antigen is a glycoprotein with collagenous domains, and a new major component of the basement memberane. June 1986 JID.
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Sinha et al find nucleotide sequence of a class II variant found almost exclusively in patients with the autoimmune skin disease pemphigus vulgaris. Science 1988.
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Variety of studies published throughout the 1990's on Fogo Selvagem, Portuguese for 'wild fire'.
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Koulu et al
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Amagai et al find that a novel epithelial cadherin is the target of autoantibodies in PV. Cell Nov 1991.
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Lui et al publish findings that autoantibodies that recognize the human BP180 ectodomain are therefore likely to play an initiatory role in the pathogenesis of bullous pemphigoid and herpes gestationis. Nov 1993 JCI.
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Guidice et al developed ELISA system to detect antibody reactivity against the MCW-1 epitope with the use of a bacterial fusion protein containing the BP180 autoantibody-reactive site.
June 1994 JID.
