RT001 Topical Botulinum Toxin

Botulism is First Discovered

Jan 31, 1820

German doctor Justinus Kerner discovers a toxin found in sausages, and he named it botulism. He discovered that it caused food poisoning. He also infers that the toxin could treat some nerve disorders in small doses, as well as excess sweating.

Timeline of Botox (topical botox)

Period: Jan 31, 1820 to May 2, 2012

This is the total span of botox, and then transitioning to topical botox.

Discovered that Botulism Stops Nerve-Muscle Communication

Jan 1, 1949

Researcher Dr. Arnold Burgen and colleagues in London discover that botulinum toxin blocks communication between nerves and muscles.

Botox is Used for Cervical Dystonia

Sep 23, 1988

Doctors begin using Botox as a treatment for involuntary contraction of neck muscles (cervical dystonia).

Discovered to be Useful for Spasms and Sweat

Aug 26, 1993

Doctors in England notice that spasm patients sweat less when treated with Botox.

Used as Cosmetic Procedure

Sep 23, 2002

FDA approves Botox injections for frown lines between the eyebrows under the name Botox Cosmetic.

Aprroved for Hyperhidrosis

Dec 13, 2004

FDA approves Botox as a treatment for severe underarm sweating.

Approved for Hand and Arm Spasms

Mar 31, 2010

FDA approves Botox as a treatment for spasms of the arms and hands in adults.

Fox News Video

Sep 28, 2011

Topical Botox News Video Here is a video featured on fox news that discusses the invention of the topical botox, and how it is going through trials, and how it will change the industry.

Successful Trials for Topial Botox

Oct 7, 2011

Second phase of trials for topical Botox are successful.

Test Subjects See Improvement in Skin

May 2, 2012

Up to 89 percent of the 553 study participants saw an improvement in their crow's feet appearances.

References

Sep 23, 2012

References Document Here is a link to the google doc whereour references are located