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Anywhere from 70-72 CE on my sources. The start of the construction was under the rule of Vespasian and it was built in Rome.
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It is officially opened by Titus with 100 days of games but is not all the way finished.
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Construction is finally completed by Domitian with adding the top part of the amphitheater.
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First documented martyrdom in the Colosseum of St. Ignatius of Antioch.
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St. Telemachus is martyred in the Colosseum of Rome. Saint Telemachus was a monk who tried to stop a gladiatorial fight in a Roman amphitheater and was stoned to death by the crowd.
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The Colosseum is damaged by an earthquake.
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Last recorded animal games in the Colosseum.