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Dante wrote The Divine Comedy. In it, were stories like The Inferno. This was one of the first works that strayed from religion.
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Chaucer published the Canterbury Tales. The Canterbury Tales was a story that was told from 29 pligrim's point of views on their pilgrimage to Canturbury. This was one of the first tales that had very little to do with religion.
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Brunelleschi designed the dome for the Cathedral of Santa Maris del Fiore in Florence, Italy. This contributed a machine that was crane like, but used oxen instead. The bonus was that you didn't have to unharness the team to make the goods go down or up.
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Da Vinci unveliled his most famous work, The Mona Lisa. This contributed that common people have enough worth, to have their face painted.
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School of Athens, I think, contributed that people, all people, have the compassity and worth to learn.
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Michelangelo unveiled one of (probably) the most famous human sculpteures made, David. This showed that humans have beauty to a world who thinks we are just sinful creatures.
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Machiavelli completed The Prince, a political novel that it's main point is that it is better to be feared by your followers that loved.