Chronological history of protein engineering By arz_victoria 2002 novel protein domain fusion 2003 novel protein folds 2004 engeneering protein binding specificity 2005 engeneering protein increased thermoshbility 2006 redesign of RNA protein bindings specific 2008 redesign of catalytic activity 2009 enzyme catalytic redesigh 2010 bimolecular enzymatic catalytic 2013 Directed evolution Directed evolution by using iterative saturation mutagenesis based on multiresidue sites 2013 Creating molecular peptide assembly machine 2014 The first artificial enzymes 2016 Discovery of the hormone asprosin Reference 2017 The mammalian circadian clock Identified additional protein components that control the mechanism of self-sustaining "hours" inside the cell. 2018 Phage display of peptides and antibodies
