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There have been three major outbreaks of plague. The Plague of Justinian in the 6th and 7th centuries is the first known attack on record, and marks the first firmly recorded pattern of bubonic plague. From historical descriptions, as much as 40 percent of the population of Constantinople died from the plague. Modern estimates suggest half of Europe's population was wiped out before the plague disappeared in the 7th century.
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It reached Sicily in October 1347 carried by twelve Genoese galleys, where it rapidly spread all over the island
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Galleys from Caffa reached Genoa and Venice in January 1348 but it was the outbreak in Pisa a few weeks later that was the entry point to northern Italy.
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After 750, major epidemic diseases appeared again in Europe until the Black Death of the 14th century
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The Third Pandemic hit China in the 1890s and devastated India, but was confined to limited outbreaks in the west.[9]
