MANUFACTURING PROCESS OF DAFLON

STAGE 1: THE HARVEST OF SMALL IMMATURE ORANGES

1 CE

Immature oranges are harvested in the orange groves of the Spanish, Moroccan and Chinese provinces, places benefiting from favorable weather conditions. Indeed, every orange blossom gives birth to four or five oranges. A single orange develops and three or four others remain immature. These immature oranges will be harvested, dried during 15 days in the sun then crushed to extract a natural substance which will be used in the manufacturing of a drug called hesperidin.

STAGE 2: BIRTH OF AN ACTIVE INGREDIENT: THE FLAVONOID FRACTION

2

Once extracted, hesperidin is transformed by an industrial process into an active substance: the flavonoid fraction. This industrial process secret confers the flavonoid fraction a composition of: 90 % diosmine and 10 % flavonoids skilfully measured.

STAGE 3: PURIFICATION OF THE FLAVONOID FRACTION

3

The flavonoid fraction is then purified and dried to remove all the impurities. The objective of this stage is to obtain a flavonoid fraction of quality.

STAGE 4: MICRONIZATION OF THE PURIFIED FLAVONOID FRACTION

4

The purified flavonoid fraction is very badly absorbed by the bowel because molecules are too big. The process of micronization thus consists in reducing the size of molecules by making them bang together. The micronized purified flavonoid fraction is then better absorbed by the body.

STAGE 5: COMPRESSION OF THE PURIFIED MICRONIZED FLAVONOID FRACTION

5

The purified micronized flavonoid fraction is then transformed into tablets of daflon 500 thanks to the machine with compression.

STAGE 6: BOX OF DAFLON 500

6

Tablets are then put under blister packaging (blister of tablets) and incorporated into the daflon box. These boxes will then join the (insert your country) pharmacies.