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Entre os aos 1803 e 1814 a Expedición Filantrópica da Varíola distribuíu a primeira vacina da historia polo mundo enteiro. Partíu da Coruña e formaron parte da mesma o impulsor, o alicantino Francisco Javier Balmis, a coruñesa Isabel Zendal Gómez e 22 nenos que cambiaron o mundo.
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