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The large ammounts of histamine cause an allergic reaction which can cause irritation and swelling in areas of the body.
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The reaction is different for different people and allergies but when treated the body goes back to it's noraml state and is prepared to deal with the allergen again when needed
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the food enters the body for the first time
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When the allergen is eaten, a IgE antibody is formed and attaches itself to cells found in the tissues in cells all over the body. The body is now prepared to deal with the allergen when it comes in contact again.
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When the food allergen enters the body again, the allergen binds to IgE antibodies and sends out signals for the body to release large amounts of Histamine