How a body reacts to food allergies By NICMARTINI Oct 27, 2016 A person eats the substance for the first time that causes an allergic reaction Oct 28, 2016 Then the body makes an antibody that detects the bad substance Oct 29, 2016 The antibody attaches itself to tissues all over the body waiting for the substance Oct 30, 2016 When the substance enters the body again, the antibodies send out a signal to the body to release large amounts of histamine Oct 31, 2016 The histamine causes the body to irritation and swelling Nov 1, 2016 The result of irritation is different depending on the person, it varies from hives, asthma, to anaphylaxis