History of Drug Research By haddad.lilly@gmail.com Jan 1, 1500 Plants, venoms, and minerals tested humans Jan 1, 1806 Discovered morphine and tested on humans Jan 1, 1850 Chemicals tested on humans Jan 1, 1890 Synthetics, dyes tested on animals Jan 1, 1920 Drugs tested on aminals and isolated organs Jan 1, 1990 Use of combinatorial libraries on human proteins and HTS Jan 1, 2000 Focused libraries