Gene identification - Marfan syndrome By facebooker_10206531296260213 Aug 1, 1979 MFS suggested as linked to Rh Literature Dec 1, 1981 MFS linked to abnormal COL1A2 Literature Jan 1, 1985 a2(I) and a1(III) collagen genes ecluded as mutant loci for MFS Literature Jan 1, 1986 More evidence accumulates excluding colagen associated genes LiteratureLiterature Aug 16, 1989 Exclusion map suggested Literature Feb 1, 1990 Connective tissue gene research dimonates, with a gene exclusion map building Literature Oct 4, 1990 Chromosome 15 suggested as location of MFS mutant Literature Feb 1, 1991 Chromosome 15 confirmed, tightly linked markers identified at 15q15-q21.3 Literature May 1, 1991 Linkage studies conclude MFS locus to be located between markers D15S48 and D15S49 Literature Jul 25, 1991 Demonstration of first MFS patient with fibrillin mutation - fibrillin locus on chromosome 15 elected as syndrome causing locus Literature Sep 1, 1991 Evidence electing fibrillin as the syndrome causing gene continues to build Literature Oct 1, 1991 Fibrillin gene mapped to chromosome 15 band q21.1 Literature Apr 2, 1992 International study results agree with previous conclusions Literature
