Dr. Bresnick and his team discovers GATA2 and "hot spots," called GATA switch sites where GATA1 and GATA2 undergo special activity.
"Research indicates that downstream genes are impacted when the switch site is altered, leading to abnormal development of the adult blood system." - Dr. Emery Bresnick
scientists were testing +9.5 GATA2 in mice and knocked out the switch site, which caused the embryos to die within 14 days.
The study appeared on the Journal of Clinical Investigation.
