FK506

By mbraaschturi

  • 1980

  • FK506 isolation

  • Total synthesis by Merck

  • Formal synthesis by Sih et al

  • Formal synthesis by Danishefsky et al

  • Total synthesis by Schreiber et al

  • First US Patent held by Merck

  • FK506 made industrially using 22nd generation bacteria

  • FDA approval for liver transplants

  • Formal total synthesis by Smith et al

  • Total synthesis by Ireland et al

  • Biosynthetic gene clusters identified

  • Total synthesis by Ireland et al

  • Formal synthesis routes proposed by Smith et al

  • International Patent under Lek Pharmaceuticals

  • 2015

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