Evolution of Insulin

First Use of Insulin

Jan 1, 1678

Elliott P. Joslin was the first to use insulin as a treatment for diabetes.

Early Treatment for Diabetes

Jan 1, 1706

John Rollo treated a patient with diabetes byrestricting their diet.

Discovery of the Liver's Purpose

Jan 1, 1850

In the early 1800s, Claude Bernard discovered that the liver stores glycagon and secreted a sugary substance into the blood.

Proven Wrong

Jan 1, 1879

Claude Bernard's liver theory is proven wrong by Von Mering

Insulin Discovered

Jan 1, 1921

Fredrick Banting of Canada discovered insulin

First Dose

Jan 11, 1922

The first dose of insulin was given to a human (failed).

Purified

Jan 23, 1922

The first purified injections were given by Collip

Commercialized

Jan 1, 1923

Insulin is produced commercially and used to treat diabetes in most western countries.

Crystallized

Jan 1, 1926

JJ Abel crystallized insulin for use.

Long lasting

Jan 1, 1936

Longer acting, protamine zinc insulin is invented.

Variation

Jan 1, 1954

Lente insulin is introduced.

Composition

Jan 1, 1955

Fredrick Sanger won a Nobel Prize for discovering the composition of insulin.

Improved Investigation

Jan 1, 1957

Soloman Berson and Rosalind Yalow improved the investigation of diabetes through the technique of immonoassay.

Synthesis

Jan 1, 1963

This is when insulin was first chemically synthesized.

3D Structure

Jan 1, 1979

Dorothy Hodgin discovered the 3-D structure of insulin.

Approval

Jan 1, 1996

FDA approved a modified human insulin (humalog).