Evolution of Insulin

  • First Use of Insulin

    First Use of Insulin

    Elliott P. Joslin was the first to use insulin as a treatment for diabetes.
  • Early Treatment for Diabetes

    Early Treatment for Diabetes

    John Rollo treated a patient with diabetes byrestricting their diet.
  • Discovery of the Liver's Purpose

    Discovery of the Liver's Purpose

    In the early 1800s, Claude Bernard discovered that the liver stores glycagon and secreted a sugary substance into the blood.
  • Proven Wrong

    Proven Wrong

    Claude Bernard's liver theory is proven wrong by Von Mering
  • Insulin Discovered

    Insulin Discovered

    Fredrick Banting of Canada discovered insulin
  • First Dose

    First Dose

    The first dose of insulin was given to a human (failed).
  • Purified

    Purified

    The first purified injections were given by Collip
  • Commercialized

    Commercialized

    Insulin is produced commercially and used to treat diabetes in most western countries.
  • Crystallized

    Crystallized

    JJ Abel crystallized insulin for use.
  • Long lasting

    Long lasting

    Longer acting, protamine zinc insulin is invented.
  • Variation

    Variation

    Lente insulin is introduced.
  • Composition

    Composition

    Fredrick Sanger won a Nobel Prize for discovering the composition of insulin.
  • Improved Investigation

    Improved Investigation

    Soloman Berson and Rosalind Yalow improved the investigation of diabetes through the technique of immonoassay.
  • Synthesis

    Synthesis

    This is when insulin was first chemically synthesized.
  • 3D Structure

    3D Structure

    Dorothy Hodgin discovered the 3-D structure of insulin.
  • Approval

    Approval

    FDA approved a modified human insulin (humalog).