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Claude Bernard discovered that the liver stored glycogen and secreted the sugary substance into the blood. Also he found that pricking the brain stem can cause temporary diabetes.
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Von Mering disproved Bernard's liver theory when he noticed that removing the pancreas causes diabetes. Him and his partner, Minkowski, tried extracting an antidiabetic substance from the pancreas but failed.
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Diabetes was treated with a daily alkaline sponge bath, sugar of lead to restrict urine flow and sometimes clear opium.
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Worked with professors and medical students to extract a substance from the pancreas of a dog and try it on other dogs, which was successful
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A boy received insulin made by banting, but failed. This same year, Collins developed purified injections which ended up lowering blood glucose levels.
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Insulin began being produced commercially by many different countries. However, it was impure and crude.
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Insulin was crystalized by J.J. Abel
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Protamine zinc insulin was produced which was more pure with less pancreatic peptides.
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Lente insulin was produced, which was more pure with less pancreatic peptides. In addition, the composition of insulin was discovered by Fredrick Sanger who distinguished 51 amino acids linked by disulphide bonds.
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Solomon Berson and Rosalind Yalow did an immunoassay which enabled small concentrations of insulin to be measured accurately.
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Diabetes is treated with a special diet and insulin, which was able to keep diabetes under control.
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Diabetes is treated with insulin or, if serious, IV fluids are used in a hospital. In addition, treatment includes daily injections of insulin, and diets.
