Diseases Presented to Amerindian Populations By stephanie.conley Jan 1, 1518 Smallpox Reaches Hispaniola Period: Jul 14, 1518 to Jul 14, 1663 Epidemics Raging in Amerindian Lands Jul 14, 1520 Smallpox Reaches Mexico Jul 14, 1520 Smallpox Appears in Guatemala Jul 14, 1526 Smallpox Hits the Inca Domain Jul 14, 1530 Measles Spreads to Mexico and Peru Jul 14, 1546 Possible Typhus Outbreak Jul 14, 1558 Influenza Epidemic Jul 14, 1663 A Second Outbreak of Smallpox