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Thomas Willis wrote a chapter describing diabetes and symptoms of the disease such as sweet urine.
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Physician Oscar linked diabetes to pancreatic function through testing the effects of removing the pancreas from dogs whereby sugar appeared in the urine.
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A team in Toronto led by Banting and Macledd which also included Best and Collip discovered insulin as a key molecule that restored function
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Clinical application of insulin was used to treat a young boy who was dying of diabetes
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The Nobel Prize was awarded to Macledd and Banting for their discovery of insulin to treat diabetes
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Insulin was the first protein where the amino acid sequence was determined leading to the Nobel Prize award to Fred Sanger
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Foundation for synthetic production of insulin was founded
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Synthetic insulin production began and can be used to make different forms of insulin for various purposes