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Perhaps the most important timeframe within Charles Darwin's lifetime, the beginning of Darwin's voyage on the ship named 'The Beagle', where Darwin would travel around South America commanded by Robert FitzRoy who had hired him to be the naturalist aboard their ship. During these five years, Darwin collected samples of animals, insects and land that would challenge and contradict the paradigm of intelligent design, and become the basis of his belief in an alternative mechanism for change.
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It was from approx. September-October of 1835 that the Beagle had spent time at the Galapagos Islands, it was at this point in Darwin's journey, and the minute differences in wildlife that he discovered there that inspired his greatest contribution, Darwin's theory of evolution.
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In 1838, after Darwin had returned from his travels, he began developing concepts unique to himself. After sharing his findings through speeches, papers and sharing specimens with fellow peers, Darwin's Theory of evolution begins to take shape
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Charles Darwin publishes his own culminating Theory on Evolution after finally going public alongside Alfred Wallace on their separate findings that came to the same conclusion. Darwin, Charles, and Leonard Kebler. 'On the Origin of Species By Means of Natural Selection' London: J. Murray, 1859.
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Another publication by Darwin that directly challenges Christian views of creationism, and indicates that we not only evolved over the years, but that we have a shared ancestry with apes! Darwin, Charles. The Descent of Man: And Selection in Relation to Sex. London: J. Murray, 1871.