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Christopher Columbus was the man that eventually founded America. He was trying to find a shorter way to China and stumbled upon an unknown land.
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Amerigo Vespucci was born
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Georg Peurbach wanted to reconcile geometric descriptive models for predicting the motions of planets by using the center of celestial spheres.
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Nicolas Copernicus made a model that placed the sun, not earth, at the center of the universe
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Giovanni Pico della Mirandola takes action on practical magic, especially, astrology, as it is called into questions traditional belief of human free will
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Peter Apian and Fracastoro noticed that the tail of the comet that year, later named Halley's Comet, pointed away from the sun, a detail also recognized by Regiomontanus
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Galileo Galilei born at Pisa, Italy
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Michelangelo Buonarroti dies at Florence
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William Shakespeare born in England, 23 April
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Newton's health fails, he collapses and borders on death; shortly thereafter, Newton dies at Kensington between 1.00 and 2.00am. On 28 March his body lays in state in Westminster Abbey where he is buried on 4 April