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The Bubonic Plague began in rats and spread to humans in Europe.
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The Bubonic Plague was spread to people and Crimea by the Europeans which killed many.
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Roughly 30 to 40% of England's population was killed by the Plague which resulted in a huge economic failure because the plague would engulf entire towns at a time. Politically this made it tough for a leader to stay strong when his people were dieing around him. Socially it was bad for the moral of the citizens.
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People began to obsess over personel hygene which cut the number of deaths by the plague. Doctors began to use a scientific aproach to medicine instead of a spiritual aproach which resulted in less infections.