Being Described and Identified

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  • 1803

    John Conrad Otto, a Philadelphia physician, publish an article recognizing that a haemorrhagic bleeding disorder primarily affected men, and ran in certain families. Otto called the males “bleeders.”

  • 1803

     John Conrad Otto, a Philadelphia physician, publish an article recognizing that a haemorrhagic bleeding disorder primarily affected men, and ran in certain families.
     Otto called the males “bleeders.”

  • 1813

    John Hay published a paper in the New England Journal of Medicine proposing that affected men could pass the trait for a bleeding disorder to their unaffected daughters.

  • 1813

     John Hay published a paper in the New England Journal of Medicine proposing that affected men could pass the trait for a bleeding disorder to their unaffected daughters.

  • 1828

    Friedrich Hopff, a student, and his professor Dr. Schonlein, are credited with coining the term “haemorrhaphilia” for the condition, later shorted to “haemophilia.”

  • 1828

     Friedrich Hopff, a student, and his professor Dr. Schonlein, were credited with coming up with the term “haemorrhaphilia” for the condition, which was later shorted to “haemophilia.”

  • 1920

    Factor I deficiency was first described.

  • 1926

    Finnish physician Erik von Willebrand published a paper describing what he called “pseudohemophilia,” a bleeding disorder affecting men and women equally. It was later named von Willebrand disease.

  • 1926

     Finnish physician, Erik von Willebrand published a paper describing “pseudohemophilia,” a bleeding disorder affecting men and women equally.
     It was later named von Willebrand disease.

  • 1940s

    Factor II and factor V deficiency were identified

  • 1947

    Dr. Alfredo Pavlovsky, a doctor in Buenos Aires, distinguished haemophilia A and haemophilia B in his lab.

  • 1947

     Dr. Alfredo Pavlovsky, a doctor in Buenos Aires, Argentina, distinguished haemophilia A and haemophilia B in his lab.

  • 1950s

    Deficiencies of FVII, X, XI and XII were first recognized.

  • 1957

    Inga Marie Nilsson and researchers at the Malmo University Hospital in Sweden determined that VWD was caused by low levels of deficient von Willebrand factor.

  • 1957

     Inga Marie Nilsson and researchers at the Malmo University Hospital in Sweden determined that VWD was caused by low levels of deficient von Willebrand factor.

  • 1960

    Factor XIII deficiency was described