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Christopher Columbus makes his first voyage to the western hemisphere.
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Brazil claimed for Portugal by Pedro Alvarez de Cabral.
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Smallpox epidemic begins in the Caribbean
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Spanish conquest of Mexico
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Spanish conquest of Peru
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Spanish discovery of silver near Potosi
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Foundation of Port Royal (Nova Scotia)
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Foundation of Jamestown.
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Foundation of Quebec.
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Foundation of New Amsterdam.
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Foundation of the Massachusetts Bay Colony.
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Smallpox epidemic in Guam.
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French and Indian war in North America.
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Captain James Cook's exploration of the Pacific Ocean.
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Establishment of the first European colony in Australia.