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Benjamin Gompertz Finds that Mortality Increases Exponentially with Age
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Anthony Cerami proposes the Maillard Reaction theory of aging stating that DNA accumulates damage due to nonenzymatic modification from sugars
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August Weismann Proposes a Difference Between Germ Line and Somatic Cells
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Clive McCay Discovers that Calorie Restriction Extends Life-Span in Rats
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Denham Harman proposes the free radical theory of aging
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Peter Medawar proposes that aging evolved into existence since the force of natural selection diminishes after reproduction
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George C. Williams expands on the theory of antagonistic pleiotropy
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Hayflick and Moorhead Characterize Cellular Senescence in Primary Human Cells
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Leslie Orgel Proposes the "Error Catastrophe" Theory of Aging
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Leonard Hayflick proposes the Cellular Theory of Aging based on the limited replicative lifespan of primary human cells
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David and Harriet Gershon Find Accumulation of Non-active Enzymes in Older Nematodes
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Richard Weindruch finds that adult mice on dietary restriction live 20% longer and have lower cancer rates
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Michael R. Rose asserts that senescence can be postponed by natural selection
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Carol W. Greider and Elizabeth H. Blackburn Discover A Specific Telomere Terminal Transferase Later Known as Telomerase
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Robert M. Sapolsky, Lewis C. Krey, and Bruce S. McEwen Propose the Glucocorticoid Cascade Hypothesis of Aging
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Thomas Johnson and David Friedman Define the AGE-1 gene
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Cynthia Kenyon finds that mutations in daf-2 and daf-16 genes cause C. elegans worms to live over twice as long
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Brian K. Kennedy et al. Discover that the Daughter Cells of Old Yeast have Shorter Life-Spans than those of Younger Strains
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Brian K. Kennedy et al. Find that SIR4-42 Extends the Life Span of Yeast by 30% and May Play a Key Role in Regulating Aging
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Daniel E. Martìnez finds that Hydra do not show signs of Biological Aging
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Andrea Bodnar, Michel Ouellette, et al. Find An Extension of Human Cell Life-Span with the Introduction of Telomerase
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Andrea Bodnar, Michel Ouellette, et al. Find An Extension of Human Cell Life-Span with the Introduction of Telomerase
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Norman E. Sharpless finds that expression of the Ink4a/Arf locus is a biomarker of aging
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Matt Kaeberlein et al. propose that the TOR and Sch9 kinases regulate longevity in yeast