AGing

  • Benjamin

    Benjamin Gompertz Finds that Mortality Increases Exponentially with Age
  • Cerami

    Anthony Cerami proposes the Maillard Reaction theory of aging stating that DNA accumulates damage due to nonenzymatic modification from sugars
  • Weissmann

    August Weismann Proposes a Difference Between Germ Line and Somatic Cells
  • McCay

    Clive McCay Discovers that Calorie Restriction Extends Life-Span in Rats
  • Harman

    Denham Harman proposes the free radical theory of aging
  • Medawar

    Peter Medawar proposes that aging evolved into existence since the force of natural selection diminishes after reproduction
  • George C. Williams

    George C. Williams expands on the theory of antagonistic pleiotropy
  • Hayflick

    Hayflick and Moorhead Characterize Cellular Senescence in Primary Human Cells
  • Orgel

    Leslie Orgel Proposes the "Error Catastrophe" Theory of Aging
  • Leonard Hayflick

    Leonard Hayflick proposes the Cellular Theory of Aging based on the limited replicative lifespan of primary human cells
  • Gershon

    David and Harriet Gershon Find Accumulation of Non-active Enzymes in Older Nematodes
  • Weindruch

    Richard Weindruch finds that adult mice on dietary restriction live 20% longer and have lower cancer rates
  • Rose

    Michael R. Rose asserts that senescence can be postponed by natural selection
  • Greider

    Carol W. Greider and Elizabeth H. Blackburn Discover A Specific Telomere Terminal Transferase Later Known as Telomerase
  • Sapiosky

    Robert M. Sapolsky, Lewis C. Krey, and Bruce S. McEwen Propose the Glucocorticoid Cascade Hypothesis of Aging
  • Johnson

    Thomas Johnson and David Friedman Define the AGE-1 gene
  • Kenyon

    Cynthia Kenyon finds that mutations in daf-2 and daf-16 genes cause C. elegans worms to live over twice as long
  • Kennedy

    Brian K. Kennedy et al. Discover that the Daughter Cells of Old Yeast have Shorter Life-Spans than those of Younger Strains
  • Kennedy

    Brian K. Kennedy et al. Find that SIR4-42 Extends the Life Span of Yeast by 30% and May Play a Key Role in Regulating Aging
  • Martinez

    Daniel E. Martìnez finds that Hydra do not show signs of Biological Aging
  • Bodnar

    Andrea Bodnar, Michel Ouellette, et al. Find An Extension of Human Cell Life-Span with the Introduction of Telomerase
  • Bodnar

    Andrea Bodnar, Michel Ouellette, et al. Find An Extension of Human Cell Life-Span with the Introduction of Telomerase
  • Sharpless

    Norman E. Sharpless finds that expression of the Ink4a/Arf locus is a biomarker of aging
  • Kaeberlein

    Matt Kaeberlein et al. propose that the TOR and Sch9 kinases regulate longevity in yeast