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Iowa becomes the first state to impose a cigarette tax on April 11th.
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In 1922 the insulin was tested on Leonard Thompson, a 14-year-old boy. The results were spectacular.
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Rosewood, Fla Massacre, the town is burnt to the ground by members of the Ku Klux Klan.
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The Indian Citizenship Act passed on June 2nd which confers citizenship on all Native Americans born within the United States.
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New Child Labor Laws are condemned over concerns of child idleness
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Miami Hurricane (or Great Miami Hurricane or the Big Blow) was an intense hurricane that devastated Miami, Florida in 1926.
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The Great Mississippi Flood of 1927 affects 700,000 people in the greatest national disaster in US history.
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The cartoon star Mickey Mouse appears on November 18th in Steamboat Willie, an animated 1928 short film produced by Walt Disney.
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1929 St. Valentine's Day Massacre on February 14th. Seven gangsters rivaling Al Capone are murdered in Chicago, Illinois.