On April 11, 1596, Shakespeare's son, Hamnet, died at age 11. Hamnet was buried at the Holy Trinity Church. This left Shakespeare with two daughters, unable to pass on his name. It is believed 'King John', a Shakespeare work, was written because of his son's passing: a mother grieves her son and questions suicide.
This is significant because many of Shakespeare's works were written to show a sense of grief and mourning for his son, the death influencing his writing.