William Shakespeare biography. By Antonio Martos García 1564 William Shakespeare was born in 1564 in Stratford-uponAvon, in England. 1576 London's first theatre opened in 1576. Period: 1576 to 1593 Shakespeare worked in London as an actor and then started writing plays too. 1580 He probably left school when he was 14 or 15. 1583 He married Anne Hathaway. They had a daughter called Susanna and twins named Judith and Hamnet. 1590 He left Stratford and went to London, the capital city of England. 1593 The plague, a terrible disease, killed thousands of people and theatres were closed. 1599 Shakespeare helped build a new theatre called The Globe. 1616 He died when he was 52 on 23 April 1616.