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The 1st Use of Insulin
Elliott P. Joslin was the first to use insulin as a treatment for diabetes. -
Diet and Diabetes
John Rollo decided that diabetes should be treated by restricting a patient's diet. -
Purpose of the Liver
In the early 1800s, Claude Bernard discovered that the liver stores glycagon and secretes a sugary substance into the blood. -
New Findings about the Liver
Bernard's findings about the liver was proven wrong by Von Mering. -
Banting
Canadian surgeon Frederick Banting visited the University of Toronto to speak to the newly appointed head of the department of physiology, John J.R. Macleod, who had studied glucose metabolism and diabetes. -
Discovery of Insulin
Fredrick Banting, from Canada, discovered insulin. -
Failed Attempt
The first dose of insulin was given to a human, which failed. -
Purification
The first purified injections of insulin were given by Collip. -
Popularity Rising
Insulin is produced commercially, and advertised, and used to treat diabetes in most western countries. -
Crystalized Insulin
JJ Abel crystallized insulin for use. -
Modifying the Material
Longer acting, protamine zinc insulin was invented. -
Lente Insulin
Lente insulin was created. -
Frank Sanger
Fredrick Sanger won a Nobel Prize for discovering the composition of insulin. -
Immunoassay
Soloman Berson and Rosalind Yalow improved the investigation of diabetes through a technique known as immunoassay. -
Modified Again
Insulin was first made chemically synthesized. -
The Structure of Insulin
Dorothy Hodgin discovered the 3-D structure of insulin. -
Humalog
The FDA approved a modified human insulin (Humalog). -
Lantus
Lantus (recombinant insulin glargine) was introduced by Sanofi Aventis US as the first analog basal insulin. -
Pramlintide
Pramlintide, brand name Symlin, was approved in the U.S. as an injectable adjunct treatment for people who use insulin at mealtimes but still fail to achieve desirable blood glucose levels. -
Invokana
FDA approved Invokana (Canagliflozin), the first in a new class of drugs known as the SGLT-2 inhibitors, for lowering elevated blood sugar in patients with type 2 diabetes. -
Gestational Diabetes and Pregnancy
The USPSTF issued a final recommendation advising all pregnant women be screened for gestational diabetes after 24 weeks of pregnancy.
