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William Clark was born
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Meriwether Lewis was born
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Lewis is asked by President Jefferson to be his secretary-aide
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Announcement of Louisiana Purchase.
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Expedition begins.
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Expedition marks first 4th of July west of the Mississippi by firing the keelboat's cannon, and naming Independence Creek.
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Corps of Discovery meet with representatives of the Oto and Missouri Indians, give peace medals, 15 star flags and other gifts.
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Near present day Sioux City, Iowa, Sgt. Charles Floyd dies of a probable burst appendix. Captains name hilltops where he is buried Floyd's Bluff and a nearby stream, Floyd's River
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Lewis commits suicide at Grinders Stand, an inn south of Nashville
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Sacagawea dies at Fort Manuel. Clark, who is St. Louis, assumes custody of Jean Baptiste, as well as her daughter, Lisette.
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William Clark dies at the home of his eldest son, Meriwether Lewis Clark. William Clark had married Julia "Judith" Hancock for whom he had named a river while on the expedition.