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Title for Mononucleosis
The infectious disease entitled, Mononucleosis started off as ‘Glandular Fever’ by a few German doctors. The name ‘Glandular Fever’ was created because of the swollen glands and lymph nodes for people who were going through this infection. -
One of many mononucleosis outbreaks
An mononucleosis outbreak in an Ohio community amoung several adults and children. -
Six ill collge students
The name of "Infectious Mononucleosis" was used to describe 6 ill college students undertaken by lymphocytosis and atypical mononuclear cells in their blood. -
Named Infectious Mononucleosis
Glandular Fever was later changed to “Infectious Mononucleosis” shorthand form “Mono” and the name was introduced by Thomas P. Sprunt and Frank A. Evans. At a point in time “Mononuclear leukocytes in reaction to acute infection(infectious mononucleosis)”, due to the causative organism, Epstein Barr Virus (EBV), it was yet to be understood. -
Accurate diagnosis
Researchers unveil a more accurate method for diagnosing the virus -
Addition to Glandular Fever
Further Paul and Burnell discovered a mysterious antibody by the name of Heterophil in Glandular Fever. -
Epstien Barr Virus
Micheal Anthony Epstein and Yvonne Barr were the two to establish, what is now called ‘Epstein Barr Virus’. They found the Epstein virus to be apart of the Herpes Virus. -
Cause
The discovery that Epstien Barr Virus was what causes mononucleosis uncovered by accident. A lab technician was examining EBV and received the infection while on vacation. She experienced fever, sore throat, fatigue, and swollen lymph nodes. She was tested positive for Epstein Barr Virus. -
Drastic Spread
At one point in time Only about 5% of adults in Western societies remain EBV uninfected. Meaning 95% of Western societies had EBV virus inside of their bodies. -
Immortalizer
After the discovery of Epstein-Barr Virus, it was discovered that the virus also attacked and immortalized B lymphocytes which is the target cell. B lymphocytes are used to secrete antibodies into body fluids. -
New Discovery
Belgian researchers found a new compound that limited the number of patients with mono infections by EBV to 2% for the population who received the vaccine, in contrast to the 10% not treated. -
Vaccine
The development of a vaccine against Epstein-Barr virus (EBV) has taken a step forward with the Canadian discovery of how EBV infection evades detection by the immune system.
