-
1785
Mark Akensidi presents major reports about a patient nicknamed "wart man", with skin nodules, skin patches on his legs, bed sores, pruritus and a huge head. -
1803
Odier introduces the term neuroma to describe the involvement of the nerve network associated with the tumor. -
1830
Schwann describes the nerve sheath cells in neurofibromas. -
1847
Virchow reported neuromas in several members of one family and, in 1863, classified the tumors of peripheral nerves into true neuromas and false neuromas. -
1901
Adrian described the hereditary transmission of NF in 20% of the cases he investigated -
1910
Verocay suggested that these nerve tumors be called neurinomas and postulated that they originate from neuroectodermal cells,which is capable of causing various types of tumors of Von Recklinghausen disease -
1916
Henshen identified the high incidence of bilateral acoustic neuromas as part of the disease -
1967
Rosman and Pearce identified changes in cortical architecture associated with mental impairment in patients with NF. -
1982
Riccardi classified NF into eight types with designations, clinical features and patterns of inheritance. -
1988
1988 - The National Institute of Health established a diagnostic criteria for NF. -
2004
Yang found that the suppression of the NF1 gene may also contribute to the molecular pathogenesis of acute myeloid leukemia, a disease that can cause greater risk of NF i. these patients that are being tested. -
2006
Levine found slightly decreased IQ and a higher rate of attention deficit in patients with NF1 -
2007
Stevenson reported that children with NF1 have decreased bone mineral density when compared to the general population. -
2012
Chaudhary showed how the therapy can treat tumors which is related to NF when chemotherapy does not work.
