-
Thomas Willis first noted the sweet smell of urine and diabetes.
-
John Rollo, Surgeon-General to the Royal Artillery, treated a patient by dietary restriction.
-
Claude Bernard discovered that the liver stored glycogen and secreted a sugary substance (glucose) into the blood. He assumed that it caused the diabetes. He later found out that when he messed with the brain stem, he caused temporary diabetes.
-
Von Mering found that when one removes ones pancreas, they have diabetes.
-
Fredrick Banting discovered insulin and tested it one dogs.
-
A 14-year-old boy became the first human patient to receive insulin made by Banting and Best. However, this failed and was given a purified injection developed by Collip later that month.
-
Lente insulin was introduced.
-
The scientific investigation of diabetes was improved by the technique of immunoassay by Solomon Berson and Rosalind Yalow.
