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South Carolina secedes from the Union. Followed within two months by Mississippi, Florida, Alabama, Georgia, Louisiana and Texas.
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The Confederate States of America is formed with Jefferson Davis, a West Point graduate and former U.S. Army officer, as president.
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Abraham Lincoln is sworn in as 16th President of the United States of America.
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At 4:30 a.m. Confederates under General Pierre Beauregard open fire in Fort Sumter in Charleston, South Carolina. The Civil War begins.
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The Union Army under General Irvin McDowell suffers a defeat at Bull Run. Confederate General Thomas J. Jackson earns the nickname "Stonewall," as his brigade resists Union attacks. Union troops fall back to Washington. President Lincoln realizes the war will be long.
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Victory for General Ulysses S. Grant in Tennessee, capturing Fort Henry, and ten days later Fort Donelson. Grant earns the nickname "Unconditional Surrender" Grant.
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Confederate surprise attack on General Ulysses S. Grant's unprepared troops at Shiloh on the Tennessee River results in a bitter struggle with 13,000 Union killed and wounded and 10,000 Confederates, more men than in all previous American wars combined.
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75,000 Federals under General John Pope are defeated by 55,000 Confederates under General Stonewall Jackson and General James Longstreet
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The bloodiest day in U.S. military history as General Robert E. Lee and the Confederate Armies are stopped at Antietam in Maryland by McClellan and numerically superior Union forces. By nightfall 26,000 men are dead, wounded, or missing. Lee then withdraws to Virginia.
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Army of the Potomac under Gen. Burnside suffers a costly defeat at Fredericksburg in Virginia with a loss of 12,653 men after 14 frontal assaults on well entrenched Rebels on Marye's Heights.
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The Union Army under General Hooker is decisively defeated by Lee's much smaller forces at the Battle of Chancellorsville in Virginia as a result of Lee's brilliant and daring tactics. Confederate General Stonewall Jackson is mortally wounded by his own soldiers. Hooker retreats
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The tide of war turns against the South as the Confederates are defeated at the Battle of Gettysburg in Pennsylvania.
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Vicksburg, the last Confederate stronghold on the Mississippi River, surrenders to General Grant and the Army of the West after a six week siege. With the Union now in control of the Mississippi, the Confederacy is effectively split in two, cut off from its western allies.
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A costly mistake by Grant results in 7,000 Union casualties in twenty minutes during an offensive against fortified Rebels at Cold Harbor in Virginia
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Abraham Lincoln is re-elected president, defeating Democrat George B. McClellan.
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General Robert E. Lee surrenders his Confederate Army to General Ulysses S. Grant at the village of Appomattox Court House in Virginia. Grant allows Rebel officers to keep their sidearms and permits soldiers to keep horses and mules.
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Lincoln and his wife Mary see the play "Our American Cousin" at Ford's Theater. During the third act of the play, John Wilkes Booth shoots the president in the head. Doctors attend to the president in the theater then move him to a house across the street. He never regains consciousness.
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The Thirteenth Amendment to the United States Constitution, passed by Congress on January 31, 1865, is finally ratified. Slavery is abolished.