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Genoese trade ships came into Sicily carring the Bubonic Plague, also refered to as the Black Death. The plague caused purplish or blackish dots to appear on the skin
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The plague started in Asia and traveled along trade routes. It went from Italy to Span, France, Germany, England, and Europe and North Africa.
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Political: Sers left manors demanding higher wages. Noboles said "No!" which caused revolts in England, France, Italy, and Belgium.
Econmical: Trade fell, prices rose.
Social: Town population fell and Jews were blamed for the plague -