Black death By Schwifty_231 541 Plague breaks out in the eastern Roman Empire killing some 10 000 people daily in Constantipole it largely died out by 750 1333 Plague breaks out in north-eastern China, killing five million people that year 1346 Plague reaches The Crimea 1347 Plague Spreads in Cyprus, Italy and Egypt 1348 Plague reaches Paris, England, Belgium, Netherlands, Cairo and Gaza 1349 Widespread persecution of Jews, with thousands burned to death plague reaches Aswan in Egypt and the entire Islamic world is now effected 1350 Plague has largely run its course in the Mediterranean basin 1351 Plague reaches Russia 1353 Some 35 million deaths from the plague recorded in China since 1333