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The government of Iranian Prime Minister Muhammad Mussadeq is overthrown in a coup orchestrated by American and British intelligence agencies.
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Ayatollah Ruhollah Khomeini, a religious leader, is exiled to Turkey after his arrest for speaking out against the shah's relationship with the United States.
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On November 4, Iranian Islamic students stormed the U.S. embassy, taking 66 hostages, mostly Americans. 14 were released before the end of November
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The U.S. tried to rescue the hostages by secretly landing aircraft and troops near Tabas, along the Dasht-e Kavir Desert in eastern Iran but the attempt was bungled.g
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All hostages were released only shortly after Ronald Reagan took office.
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Revelations emerge of an American deal to exchange arms for Iranian help in freeing hostages held in Lebanon.
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An American naval warship patrolling in the Persian Gulf has shot down an Iranian passenger jet after apparently mistaking it for an F-14 fighter.
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Clinton signs an executive order banning trade with Iran.
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Clinton stiffens sanctions with penalties against any firm that invests $40m or more a year in oil and gas projects in Iran and Libya.
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US President George W Bush, in his State of the Union address, describes Iran, Iraq and North Korea as an "axis of evil". He warns that the proliferation of long-range missiles being developed in these countries is as great a danger to the US as terrorism.
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The US accuses Iran of seeking to develop a secret nuclear weapons programme and publishes satellite images of two nuclear sites under construction at Natanz and Arak.
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US sends humanitarian aid to Iran after earthquake kills up to 50,000 people in city of Bam.
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The US concludes that President Ahmadinejad was a leader of the group behind the 1979 hostage crisis at its embassy in Tehran.
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Iran's Supreme Leader, Ayatollah Ali Khamenei, said relations with the US could be restored in the future.
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President Mahmoud Ahmadinejad offers congratulations to Barack Obama after his election as US president. During the election campaign, Mr Obama had offered talks with Iran without preconditions.